Publications

Bacterial Colonization on the Surface of Copper Sulfide Minerals Probed by Fourier Transform Infrared Micro-Spectroscopy

C Varotsis, M Papageorgiou, C Tselios, KA Yiannakkos, A Adamou, …
Crystals 10 (11), 1002 , 2020
    

Photoreduction of carotenoids in the aerobic anoxygenic photoheterotrophs probed by real time Raman spectroscopy

M Papageorgiou, C Tselios, C Varotsis
Journal of Photochemistry and Photobiology B: Biology, 112069 , 2020
    

Resonance Raman investigation of the Reaction of Cytochrome c Oxidase NO2

C Tselios, C Varotsis
2019-Sustainable Industrial Processing Summit 11, 153-158
    

Sulfobacillus Thermo Sulfidooxidans Electron Uptake from Cu-Fe Based p Electron Surface-Donors Probed by Raman and FTIR Spectroscopies

M Papageorgiou, C Tselios, C Varotsis
2019-Sustainable Industrial Processing Summit 4, 187-192

Discrete Ligand Binding and Electron Transfer Properties of ba3-Cytochrome c Oxidase from Thermus thermophilus: Evolutionary Adaption to Low Oxygen and …

C Koutsoupakis, T Soulimane, C Varotsis
Accounts of chemical research, 2019
    

Bio-hydrometallurgy dynamics of copper sulfide-minerals probed by micro-FTIR mapping and Raman microspectroscopy

A Adamou, A Nicolaides, C Varotsis
Minerals Engineering 132, 39-47, 2019
    

Probing hemoglobin glyco-products by fluorescence spectroscopy

A Ioannou, C Varotsis
RSC Advances 9 (64), 37614-37619, 2019
    

Photosensitivity responses of Sagittula stellata probed by FTIR, fluorescence and Raman microspectroscopy

M Papageorgiou, C Tselios, C Varotsis
RSC advances 9 (47), 27391-27397, 2019
    

Extracellular electron uptake from carbon-based π electron surface-donors: oxidation of graphite sheets by Sulfobacillus thermosulfidooxidans probed by Raman and FTIR …

C Tselios, M Papageorgiou, C Varotsis
RSC Advances 9 (33), 19121-19125, 2019
    

Reversible temperature-dependent high-to low-spin transition in the heme Fe–Cu binuclear center of cytochrome ba 3 oxidase

A Nicolaides, T Soulimane, C Varotsis
RSC advances 9 (9), 4776-4780, 2019
    

Reaction of Hemoglobin With the Schiff Base Intermediate of the Glucose/Asparagine Reaction: Formation of a Hemichrome

A Ioannou, C Varotsis
Polyphenols in Plants, 317-325, 2019
    

Metal (Ag/Ti)-containing hydrogenated amorphous carbon nanocomposite films with enhanced nanoscratch resistance: Hybrid PECVD/PVD system and microstructural characteristics

M Constantinou, P Nikolaou, L Koutsokeras, A Avgeropoulos, …
Nanomaterials 8 (4), 209, 2018
    

Modifications of hemoglobin and myoglobin by Maillard reaction products (MRPs)

A Ioannou, C Varotsis
PloS one 12 (11), e0188095, 2017
    

Detection of Maillard reaction products by a coupled HPLC-Fraction collector technique and FTIR characterization of Cu (II)-complexation with the isolated species

A Ioannou, V Daskalakis, C Varotsis
Journal of Molecular Structure 1141, 634-642, 2017
    

Resonance Raman of ba (3) oxidase from Thermus thermophilus: detection of a ferryl-oxo species and a low to high temperature transition

A Nicolaides, T Soulimane, C Varotsis
Springer-Verlag, 2017
    

Nanosecond ligand migration and functional protein relaxation in ba3 oxidoreductase: Structures of the B0, B1 and B2 intermediate states

A Nicolaides, T Soulimane, C Varotsis
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1857 (9), 1534-1540, 2016
    

Probing the whole ore chalcopyrite–bacteria interactions and jarosite biosynthesis by Raman and FTIR microspectroscopies

A Adamou, G Manos, N Messios, L Georgiou, C Xydas, C Varotsis
Bioresource technology 214, 852-855, 2016
    

Identification of the Schiff base intermediate in the Glucose/Asparagine reaction by coupled HPLC-FTIR spectroscopy

A Ioannou, C Varotsis
Journal of International Society of Antioxidants in Nutrition & Health 3 (2), 2016
    

Real time monitoring the Maillard reaction intermediates by HPLC-FTIR

A Ioannou, C Varotsis
CA OMICS International, 2016
    

ns-μs Time-Resolved Step-Scan FTIR of ba3 Oxidoreductase from Thermus thermophilus: Protonic Connectivity of w941-w946-w927

A Nicolaides, T Soulimane, C Varotsis
International journal of molecular sciences 17 (10), 1657, 2016
    

Structure and properties of the catalytic site of nitric oxide reductase at ambient temperature

V Daskalakis, T Ohta, T Kitagawa, C Varotsis
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1847 (10), 1240-1244, 2015
    

Alleviation of organic solvent inhibition with improved copper recovery from low grade sulphide ore by bioaugmentation with newly isolated Candida sp. OR3 and OR6

I Vyrides, E Xenofontos, MD Tsolakidou, IS Pantelides, C Varotsis, …
Minerals Engineering 79, 84-87, 2015
    

Photobiochemical Production of Carbon Monoxide by Thermus thermophilus ba3‐Cytochrome c Oxidase

C Koutsoupakis, T Soulimane, C Varotsis
Chemistry–A European Journal 21 (13), 4958-4961, 2015
    

Detection of functional hydrogen-bonded water molecules with protonated/deprotonated key carboxyl side chains in the respiratory enzyme ba 3-oxidoreductase

A Nicolaides, T Soulimane, C Varotsis
Physical Chemistry Chemical Physics 17 (12), 8113-8119, 2015
    

Nitric oxide activation by caa 3 oxidoreductase from Thermus thermophilus

T Ohta, T Soulimane, T Kitagawa, C Varotsis
Physical Chemistry Chemical Physics 17 (16), 10894-10898, 2015
    

Probing the formation of secondary minerals in the bioleaching reactions of chalcopyrite by Raman and FTIR microspectroscopy

C Varotsis, C Giangou, S Papadatos, E Xenofontos, I Vyrides, G Manos, …
New Biotechnology, S139, 2014
    

Probing the mechanism of acrylamide formation by HPLC-FTIR and Raman spectroscopy

A Ioannou, A Ioannou, C Varotsis
Springer, 2014
    

Probing the Action of Cytochrome c Oxidase

V Daskalakis, C Varotsis
The Structural Basis of Biological Energy Generation, 187-198, 2014
    

The protein effect in the structure of two ferryl-oxo intermediates at the same oxidation level in the heme copper binuclear center of cytochrome c oxidase

E Pinakoulaki, V Daskalakis, T Ohta, OMH Richter, K Budiman, …
Journal of Biological Chemistry 288 (28), 20261-20266, 2013
    

The structure of two ferryl-oxo intermediates at the same oxidation level in the hemecopper binuclear center of cytochrome c oxidase: the protein effect: SW02. S6–31

C Varotsis, E Pinakoulaki, V Daskalakis, T Ohta, OM Richter, K Budiman, …
The Febs Journal 280 (1), 2013
    

Detection of the hyponitrite species (HO-N=N-O) in denitrification: Reactivity of NO with the heme Fe-Cu center of cytochrome caa3 and the heme Fe –Fe center of …

C Varotsis, E Pinakoulaki, T Ohta, T Kitagawa
The FASEB Journal 27 (1_supplement), lb64-lb64, 2013
    

The structure of the hyponitrite in nitric oxide reductase (NOR)

E Daskalakis, C Varotsis
 
    

Spectroscopic and Kinetic Investigation of the Fully Reduced and Mixed Valence States of ba3-Cytochrome c Oxidase from Thermus thermophilus A FOURIER TRANSFORM INFRARED (FTIR …

C Koutsoupakis, T Soulimane, C Varotsis
Journal of Biological Chemistry 287 (44), 37495-37507, 2012
    

Tuning heme functionality: the cases of Cytochrome c Oxidase and Myoglobin Oxidation

V Daskalakis, SC Farantos, C Varotsis
International Conference on Computational Science and Its Applications, 304-315, 2012
    

Non-linear vibrational modes in biomolecules: A periodic orbits description

A Kampanarakis, SC Farantos, V Daskalakis, C Varotsis
Chemical Physics 399, 258-263, 2012
    

The origin of the FeIV= O intermediates in cytochrome aa3 oxidase

E Pinakoulaki, V Daskalakis, C Varotsis
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1817 (4), 552-557, 2012
    

Non-linear vibrational modes in biomolecules: a periodic orbits description

SC Farantos, A Kampanarakis, C Varotsis, E Daskalakis
Elsevier, 2012
    

origin of the Feᴵⱽ= O intermediates in cytochrome aa₃ oxidase

E Pinakoulaki, V Daskalakis, C Varotsis
Biochimica et biophysica acta, 2012
    

The origin of the Fe IV= O intermediates in cytochrome aa 3 oxidase

C Varotsis, E Pinakoulaki, E Daskalakis
Elsevier, 2012
    

Probing protonation/deprotonation of tyrosine residues in cytochrome ba3 oxidase from Thermus thermophilus by time-resolved step-scan Fourier transform infrared spectroscopy

C Koutsoupakis, O Kolaj-Robin, T Soulimane, C Varotsis
Journal of Biological Chemistry 286 (35), 30600-30605, 2011
    

Regulation of electron and proton transfer by the protein matrix of cytochrome c oxidase

V Daskalakis, SC Farantos, V Guallar, C Varotsis
The Journal of Physical Chemistry B 115 (13), 3648-3655, 2011
    

Regulation of electron and proton transfer by the protein matrix of cytochrome C oxidase

SC Farantos, V Guallar, C Varotsis, E Daskalakis
ACS Publications, 2011
    

Probing protonation/deprotonation of tyrosine residues in cytochrome ba 3 oxidase from thermus thermophilus by time-resolved step-scan fourier transform infrared spectroscopy

O Kolaj-Robin, T Soulimane, C Varotsis, C Koutsoupakis
The American Society for Biochemistry and Molecular Biology, 2011
    

Probing the effect of the proximal and distal to the heme a3 environments in the Cytochrome c Oxidase dioxygen reaction

E Daskalakis, C Varotsis
 
    

Vibrational resonances and Cu B displacement controlled by proton motion in cytochrome c oxidase

SC Farantos, V Guallar, C Varotsis, E Daskalakis
ACS Publications, 2010
    

QM/MM Calculations on Cyto-chrome c Oxidase: Probing of electron and proton pump coupling

E Daskalakis, SC Farantos, V Guallar, C Varotsis
 
    

Vibrational resonances and CuB displacement controlled by proton motion in cytochrome c oxidase

V Daskalakis, SC Farantos, V Guallar, C Varotsis
The Journal of Physical Chemistry B 114 (2), 1136-1143, 2009
    

Binding and docking interactions of NO, CO and O2 in heme proteins as probed by density functional theory

V Daskalakis, C Varotsis
International journal of molecular sciences 10 (9), 4137-4156, 2009
    

Heme Cavity Dynamics of Photodissociated CO from ba3-Cytochrome c Oxidase: The Role of Ring-D Propionate

M Porrini, V Daskalakis, SC Farantos, C Varotsis
The Journal of Physical Chemistry B 113 (35), 12129-12135, 2009
    

Binding and docking interactions of NO, CO and O 2 in heme proteins as probed by density functional theory

C Varotsis, E Daskalakis
MDPI, 2009
    

Cytochrome c Oxidase+ O2 reaction intermediates as probed by Density Functional Theory: The Proximal and Distal to heme a3 effects

E Daskalakis, C Varotsis
 
    

Towards the Understanding of His411-FeIV= O Spectroscopic Properties in Ferryl Intermediate of Cytochrome c Oxi-dase+ O2 Reaction: A Theoretical QM/MM, MD Approach

E Daskalakis, SC Farantos, V Guallar, C Varotsis
 
    

ORAL PRESENTATION

M Wikstrom, C Varotsis, V Daskalakis, E Pinakoulaki
J Biol Inorg Chem 14 (1), S11-S20, 2009
    

Assigning vibrational spectra of ferryl-oxo intermediates of cytochrome c oxidase by periodic orbits and molecular dynamics

V Daskalakis, SC Farantos, C Varotsis
Journal of the American Chemical Society 130 (37), 12385-12393, 2008
    

Nitric oxide activation and reduction by heme–copper oxidoreductases and nitric oxide reductase

E Pinakoulaki, C Varotsis
Journal of inorganic biochemistry 102 (5-6), 1277-1287, 2008
    

Resonance Raman spectroscopy of nitric oxide reductase and cbb 3 heme-copper oxidase

E Pinakoulaki, C Varotsis
The Journal of Physical Chemistry B 112 (6), 1851-1857, 2008
    

Assigning vibrational spectra of ferryl-oxo intermediates of cytochrome c oxidase by periodic orbits and molecular dynamics

SC Farantos, C Varotsis, E Daskalakis
ACS Publications, 2008
    

Protein Dynamics and Spectroscopy for Ferryl Intermediate of Cytochrome c Oxidase: A Molecular Dynamics Approach

V Daskalakis, SC Farantos, C Varotsis
AIP Conference Proceedings 963 (2), 31-34, 2007
    

Probing the Environment of CuB in Heme−Copper Oxidases

E Pinakoulaki, C Varotsis, E Daskalakis
ACS Publications
    

The Structure of the Hyponitrite Species in a Heme Fe Cu Binuclear Center

C Varotsis, T Ohta, T Kitagawa, T Soulimane, E Pinakoulaki
Angewandte Chemie International Edition 46 (13), 2210-2214, 2007
    

Probing the environment of Cu B in heme-copper oxidases

E Pinakoulaki, C Varotsis, E Daskalakis
ACS Publications, 2007
    

The structure of the hyponitrite species in a heme Fe-Cu binuclear center

T Ohta, T Kitagawa, C Varotsis
Wiley, 2007
    

Protein dynamics and spectroscopy for ferryl intermediate of cytochrome c oxidase: a molecular dynamics approach

SC Farantos, C Varotsis, E Daskalakis
AIP, 2007
    

Two ligand-binding sites in the O2-sensing signal transducer HemAT: Implications for ligand recognition/discrimination and signaling

E Pinakoulaki, H Yoshimura, V Daskalakis, S Yoshioka, S Aono, …
Proceedings of the National Academy of Sciences 103 (40), 14796-14801, 2006
    

Recognition and discrimination of gases by the oxygen-sensing signal transducer protein HemAT as revealed by FTIR spectroscopy

E Pinakoulaki, H Yoshimura, S Yoshioka, S Aono, C Varotsis
Biochemistry 45 (25), 7763-7766, 2006
    

Characterization of a bimetallic-bridging intermediate in the reduction of NO to N2O: a density functional theory study

T Ohta, T Kitagawa, C Varotsis
Inorganic chemistry 45 (8), 3187-3190, 2006
    

Diogygen activation and bond cleavage in cell respiration as probed by resonance raman spectroscopy

E Pinakoulaki, T Ohta, E Daskalakis, M Aggelaki, T Kitagawa, B Ludwig, …
 
    

Detection of the His-Heme Fe2+−NO Species in the Reduction of NO to N2O by ba3-Oxidase from Thermus thermophilus

E Pinakoulaki, T Ohta, T Soulimane, T Kitagawa, C Varotsis
Journal of the American Chemical Society 127 (43), 15161-15167, 2005
    

Structural dynamics of heme–copper oxidases and nitric oxide reductases: time‐resolved step‐scan Fourier transform infrared and time‐resolved resonance Raman studies

E Pinakoulaki, C Koutsoupakis, S Stavrakis, M Aggelaki, G Papadopoulos, …
Journal of Raman Spectroscopy: An International Journal for Original Work in …, 2005
    

Detection of the primary ferrous nitrosyl heme, Fe2+-NO intermediate in the reduction of NO to N20 by cytochrome ba3 oxidase from Thermus thermophilus

E Pinakoulaki, T Ohta, V Daskalakis, I Gialou, T Kitagawa, T Soulimane, …
BIOPHYSICAL JOURNAL 88 (1), 391A-391A, 2005
    

Resonance Raman Detection of the Fe2+−C−N Modes in Heme−Copper Oxidases:  A Probe of the Active Site

E Pinakoulaki, M Vamvouka, C Varotsis
Inorganic chemistry 43 (16), 4907-4910, 2004
    

Simultaneous Resonance Raman Detection of the Heme a3-Fe-CO and CuB-CO Species in CO-bound ba3-Cytochrome c Oxidase from Thermus thermophilus EVIDENCE FOR A CHARGE TRANSFER CuB …

E Pinakoulaki, T Ohta, T Soulimane, T Kitagawa, C Varotsis
Journal of Biological Chemistry 279 (22), 22791-22794, 2004
    

Detection of a Photostable Five-Coordinate Heme a 3-Fe− CO Species and Functional Implications of His384/α10 in CO-Bound ba 3-Cytochrome c Oxidase from Thermus thermophilus

T Ohta, E Pinakoulaki, T Soulimane, T Kitagawa, C Varotsis
The Journal of Physical Chemistry B 108 (18), 5489-5491, 2004
    

Time-resolved step-scan Fourier transform infrared investigation of heme-copper oxidases: implications for O2 input and H2O/H+ output channels

C Koutsoupakis, E Pinakoulaki, S Stavrakis, V Daskalakis, C Varotsis
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1655, 347-352, 2004
    

Probing the Q-proton pathway of ba3-cytochrome c oxidase by time-resolved Fourier transform infrared spectroscopy

C Koutsoupakis, T Soulimane, C Varotsis
Biophysical journal 86 (4), 2438-2444, 2004
    

Detection of a Photostable Five-Coordinate Heme a3-Fe-CO Species and Functional Implications of His384/r10 in CO-Bound ba3-Cytochrome c Oxidase from Thermus thermophilus

T Ohta, E Pinakoulaki, T Soulimane, T Kitagawa, C Varotsis
 
    

ACCELERATED PUBLICATIONS-Simultaneous Resonance Raman Detection of the Heme a3-Fe-CO and CuB-CO Species in CO-bound ba3-Cytochrome c Oxidase from Thermus thermophilus. EVIDENCE …

E Pinakoulaki, T Ohta, T Soulimane, T Kitagawa, C Varotsis
Journal of Biological Chemistry 279 (22), 22791-22794, 2004
    

Detection of a photostable five-coordinate heme a3-Fe-Co species and functional implications of His384/α10 in CO-bound ba 3-cytochrome c oxidase from Thermus thermophilus

E Pinakoulaki, T Ohta, C Varotsis
ACS Publications, 2004
    

Probing the Q-Proton pathway of ba3-cytochrome c oxidase by time-resolved fourier transform infrared spectroscopy

T Soulimane, C Varotsis, C Koutsoupakis
Elsevier, 2004
    

Time-Resolved Resonance Raman and Time-Resolved Step-Scan FTIR Studies of Nitric Oxide Reductase from Paracoccus denitrificans: Comparison of the Heme b 3-FeB Site to That of …

E Pinakoulaki, C Varotsis
Biochemistry 42 (50), 14856-14861, 2003
    

Ligand binding in a docking site of cytochrome c oxidase: a time-resolved step-scan Fourier transform infrared study

C Koutsoupakis, T Soulimane, C Varotsis
Journal of the American Chemical Society 125 (48), 14728-14732, 2003
    

Docking site dynamics of ba3-cytochrome c oxidase from Thermus thermophilus

C Koutsoupakis, T Soulimane, C Varotsis
Journal of Biological Chemistry 278 (38), 36806-36809, 2003
    

The Active Site Structure of Heme a 33+ C⋮ N CuB2+ of Cytochrome aa 3 Oxidase as Revealed from Resonance Raman Scattering

E Pinakoulaki, M Vamvouka, C Varotsis
The Journal of Physical Chemistry B 107 (36), 9865-9868, 2003
    

Direct detection of Fe (IV)= O intermediates in the cytochrome aa3 oxidase from Paracoccus denitrificans/H2O2 reaction

E Pinakoulaki, U Pfitzner, B Ludwig, C Varotsis
Journal of Biological Chemistry 278 (21), 18761-18766, 2003
    

Oxygen-linked Equilibrium CuB-CO Species in Cytochrome ba 3 Oxidase from Thermus thermophilus IMPLICATIONS FOR AN OXYGEN CHANNEL AT THE CuBSITE

K Koutsoupakis, S Stavrakis, T Soulimane, C Varotsis
Journal of Biological Chemistry 278 (17), 14893-14896, 2003
    

Oxygen-linked equilibrium Cu B-CO species in cytochrome ba 3 oxidase from Thermus thermophilus: implications for an oxygen channel at the Cu B site

C Varotsis, C Koutsoupakis
American Society for Biochemistry and Molecular Biology, 2003
    

Docking site dynamics of ba3-cytochrome c oxidase from thermus thermophilus

T Soulimane, C Varotsis, C Koutsoupakis
The American Society for Biochemistry and Molecular Biology, 2003
    

Ligand binding in a docking site of cytochrome c oxidase: a time-resolved step-scan fourier transform infrared study

T Soulimane, C Varotsis, C Koutsoupakis
ACS Publications, 2003
    

ENZYME CATALYSIS AND REGULATION-Direct Detection of Fe (IV)= O Intermediates in the Cytochrome aa3 Oxidase from Paracoccus denitrificans/H2O2 Reaction.

E Pinakoulaki, U Pfitzner, B Ludwig, C Varotsis
Journal of Biological Chemistry 278 (21), 18761-18766, 2003
    

Oxygen-linked Equilibrium CuB-CO Species in Cytochrome ba3 Oxidase from Thermus thermophilus

K Koutsoupakis, S Stavrakis, T Soulimane, C Varotsis
 
    

Direct Detection of Fe (IV) O Intermediates in the Cytochrome aa

E Pinakoulaki, U Pfitzner, B Ludwig, C Varotsis
 
    

Oxygen-linked Equilibrium Cu

K Koutsoupakis, S Stavrakis, T Soulimane, C Varotsis
 
    

ENZYME CATALYSIS AND REGULATION-Oxygen-linked Equilibrium CuB-CO Species in Cytochrome ba3 Oxidase from Thermus thermophilus. IMPLICATIONS FOR AN OXYGEN CHANNEL AT THE CuB SITE.

K Koutsoupakis, S Stavrakis, T Soulimane, C Varotsis
Journal of Biological Chemistry 278 (17), 14893-14896, 2003
    

Docking Site Dynamics of ba

C Koutsoupakis, T Soulimane, C Varotsis
 
    

Fourier transform infrared evidence for a ferric six-coordinate nitrosylheme b 3 complex of cytochrome cbb 3 oxidase from Pseudomonas stutzeri at ambient temperature

S Stavrakis, E Pinakoulaki, A Urbani, C Varotsis
The Journal of Physical Chemistry B 106 (50), 12860-12862, 2002
    

Fourier Transform Infrared (FTIR) and Step-scan Time-resolved FTIR Spectroscopies Reveal a Unique Active Site in Cytochromecaa 3 Oxidase from Thermus thermophilus

E Pinakoulaki, T Soulimane, C Varotsis
Journal of Biological Chemistry 277 (36), 32867-32874, 2002
    

Observation of the Equilibrium CuB-CO Complex and Functional Implications of the Transient Hemea 3 Propionates in Cytochromeba 3-CO from Thermus thermophilus FOURIER TRANSFORM …

K Koutsoupakis, S Stavrakis, E Pinakoulaki, T Soulimane, C Varotsis
Journal of Biological Chemistry 277 (36), 32860-32866, 2002
    

Resonance Raman Detection of a Ferrous Five-Coordinate Nitrosylheme b 3 Complex in Cytochrome cbb 3 Oxidase from Pseudomonas s tutzeri

E Pinakoulaki, S Stavrakis, A Urbani, C Varotsis
Journal of the American Chemical Society 124 (32), 9378-9379, 2002
    

FTIR and step-scan time-resolved FTIR spectroscopies reveal a unique active site in cytochrome caa3 oxidase from Thermus Thermophilus

E Pinakoulaki, T Soulimane, C Varotsis
Journal of Biological Chemistry, 2002
    

Nitric-oxide reductase structure and properties of the catalytic site from resonance Raman scattering

E Pinakoulaki, S Gemeinhardt, M Saraste, C Varotsis
Journal of Biological Chemistry 277 (26), 23407-23413, 2002
    

The role of the cross-link His-Tyr in the functional properties of the binuclear center in cytochrome c oxidase

E Pinakoulaki, U Pfitzner, B Ludwig, C Varotsis
Journal of biological chemistry 277 (16), 13563-13568, 2002
    

Decay of the Transient CuB−CO Complex Is Accompanied by Formation of the Heme Fe−CO Complex of Cytochrome cbb3−CO at Ambient Temperature …

S Stavrakis, K Koutsoupakis, E Pinakoulaki, A Urbani, M Saraste, …
Journal of the American Chemical Society 124 (15), 3814-3815, 2002
    

DFT Study of endoperoxides and their in-termediates in Fe (II) cleavage of the endoperoxy bridge

E Daskalakis, G Frudakis, C Varotsis
 
    

Antimalarial endoperoxides: synthesis and implications of the mode of action

I Gialou, C Varotsis, C Koutsoupakis
ARKAT USA, Inc., 2002
    

Observation of the equilibrium Cu B-CO complex and functional implications of the transient heme a 3 propionates in cytochrome ba 3-CO from Thermus thermophilus. Fourier …

S Stavrakis, C Varotsis, C Koutsoupakis
American Society for Biochemistry and Molecular Biology, 2002
    

Nitric-oxide Reductase

E Pinakoulaki, S Gemeinhardt, M Saraste, C Varotsis
 
    

ENZYME CATALYSIS AND REGULATION-Observation of the Equilibrium CuB-CO Complex and Functional Implications of the Transient Heme a3 Propionates in Cytochrome ba3-CO from Thermus …

K Koutsoupakis, S Stavrakis, E Pinakoulaki, T Soulimane, C Varotsis
Journal of Biological Chemistry 277 (36), 32860-32866, 2002
    

ENZYME CATALYSIS AND REGULATION-Fourier Transform Infrared (FTIR) and Step-scan Time-resolved FTIR Spectroscopies Reveal a Unique Active Site in Cytochrome caa3 Oxidase from …

E Pinakoulaki, T Soulimane, C Varotsis
Journal of Biological Chemistry 277 (36), 32867-32874, 2002
    

Observation of the Equilibrium Cu

K Koutsoupakis, S Stavrakis, E Pinakoulaki, T Soulimane, C Varotsis
 
    

Antimalarial endoperoxides: synthesis and implications of the mode of action

C Koutsoupakis, I Gialou, E Pavlidou, S Kapetanaki, C Varotsis
Arkivoc 13, 62-69, 2002
    

Fourier transform infrared investigation of non-heme Fe (III) and Fe (II) decomposition of artemisinin and of a simplified trioxane alcohol

S Kapetanaki, C Varotsis
Journal of medicinal chemistry 44 (19), 3150-3156, 2001
    

Ferryl–oxo heme intermediate in the antimalarial mode of action of artemisinin

S Kapetanaki, C Varotsis
FEBS letters 474 (2-3), 238-241, 2000
    

Picosecond resonance Raman evidence of the structure of a long-lived electronic excited state of low-spin Fe (III) heme o

JPM Schelvis, CA Varotsis
Chemical Physics Letters 321 (1-2), 37-42, 2000
    

Resonance Raman and Fourier Transform Infrared Detection of Azide Binding to the Binuclear Center of Cytochrome bo 3 Oxidase from Escherichia c oli

C Varotsis, M Vamvouka
The Journal of Physical Chemistry B 103 (19), 3942-3946, 1999
    

Infrared observation of CuBCO and deprotonation of a carboxylic side chain for photodissociated CO-cytochrome c oxidase

T Iwase, C Varotsis, Y Kim, K Shinzawa-Itoh, S Yoshikawa, T Kitagawa
JOURNAL OF INORGANIC BIOCHEMISTRY 74 (1-4), 192-192, 1999
    

Fourier transform infrared and resonance Raman studies of the interaction of azide with cytochrome c oxidase from Paracoccus denitrificans

M Vamvouka, W Müller, B Ludwig, C Varotsis
The Journal of Physical Chemistry B 103 (15), 3030-3034, 1999
    

Infrared evidence for CuB ligation of photodissociated CO of cytochrome c oxidase at ambient temperatures and accompanied deprotonation of a carboxyl side chain of protein

T Iwase, C Varotsis, K Shinzawa-Itoh, S Yoshikawa, T Kitagawa
Journal of the American Chemical Society 121 (6), 1415-1416, 1999
    

Resonance Raman and fourier transform infrared detection of azide binding to the binuclear center of cytochrome bo3, oxidase from Escherichia coli

M Vamvouka, C Varotsis
ACS Publications, 1999
    

BIOPHYSICAL CHEMISTRY-Fourier Transform Infrared and Resonance Raman Studies of the Interaction of Azide with Cytochrome c Oxidase from Paracoccus denitrificans

M Vamvouka, W Muller, B Ludwig, C Varotsis
Journal of Physical Chemistry B-Condensed Phase 103 (15), 3030-3034, 1999
    

Resonance Raman scattering from heme o complexes and cytochrome bo 3 oxidase

W Wu, C Chang, C Varotsis
Hindawi Publishing Corporation, 1999
    

Resonance Raman Scattering from Heme O Complexes and Cytochrome bo3 0xidase

C Varotsis, W Wu, CK Chang, GT Babcock, M Wikström, A Puustinen
Laser Chemistry 19 (1-4), 227-228, 1999
    

Resonance Raman and FTIR Studies of Carbon Monoxide-Bound Cytochrome aa3-600 Oxidase of Bacillus subtilis

C Varotsis, M Vamvouka
The Journal of Physical Chemistry B 102 (39), 7670-7673, 1998
    

Resonance raman and FTIR studies of carbon monoxide-bound cytochrome aa3-600 oxidase of bacillus subtilis

M Vamvouka, C Varotsis
ACS Publications, 1998
    

Ligand Dynamics in the Binuclear Site in Cytochrome Oxidase

GT Babcock, G Deinum, J Hosler, Y Kim, M Pressler, DA Proshlyakov, …
Oxygen Homeostasis and its Dynamics, 47-56, 1998
    

Low-power picosecond resonance Raman evidence for histidine ligation to heme a 3 after photodissociation of CO from cytochrome c oxidase

JPM Schelvis, G Deinum, CA Varotsis, S Ferguson-Miller, GT Babcock
Journal of the American Chemical Society 119 (36), 8409-8416, 1997
    

Dioxygen activation in enzymatic systems and in inorganic models

GT Babcock, R Floris, T Nilsson, M Pressler, C Varotsis, E Vollenbroek
Inorganica chimica acta 243 (1-2), 345-353, 1996
    

Cytochrome o3 hemepocket relaxation subsequent to carbon monoxide photolysis from fully reduced and mixed valence cytochrome bo3 oxidase

D Kreszowski, G Babcock, C Varotsis
Wiley, 1996
    

Cytochrome o3 hemepocket relaxation subsequent to carbon monoxide photolysis from fully reduced and mixed valence cytochrome bo3 oxidase

C Varotsis, DH Kreszowski, GT Babcock
Biospectroscopy 2 (5), 331-338, 1996
    

Resonance Raman spectroscopy of the heme groups of cytochrome cbb3 in Rhodobacter sphaeroides

C Varotsis, GT Babcock, JA Garcia-Horsman, RB Gennis
The Journal of Physical Chemistry 99 (46), 16817-16820, 1995
    

Photolytic activity of early intermediates in dioxygen activation and reduction by cytochrome oxidase

CA Varotsis, GT Babcock
Journal of the American Chemical Society 117 (45), 11260-11269, 1995
    

Resonance raman spectroscopy of the heme groups of cytochrome cbb3 in hodobacter sphaeroides

G Babcock, JA García-Horsman, C Varotsis
ACS Publications, 1995
    

Photolytic activity of early intermediates in dioxygen activation and reduction by cytochrome oxidase

G Babcock, C Varotsis
ACS Publications, 1995
    

Raman detection of a peroxy intermediate in the hydroquinone-oxidizing cytochrome aa3, of Bacillus subtilis

G Babcock, M Lauraeus, C Varotsis
Elsevier, 1995
    

Nickel Coordination Chemistry with Oxothiolate Ligands and Its Relevance to Hydrogenase Enzymes

JH Chou, C Varotsis, MG Kanatzidis
Bioinorganic Chemistry, 333-348, 1995
    

Photodissociated Cytochrome bo Oxidase: A Time-Resolved Raman Study of the FE-HIS Stretching Mode

C Varotsis, DH Kreszowski, GT Babcock, A Puustinen, M Wikström
Spectroscopy of Biological Molecules, 129-130, 1995
    

Syntheses, structures, and properties of six novel alkali metal tin sulfides: K2Sn2S8,. alpha.-Rb2Sn2S8,. beta.-Rb2Sn2S8, K2Sn2S5, Cs2Sn2S6, and Cs2SnS14

JH Liao, C Varotsis, MG Kanatzidis
Inorganic Chemistry 32 (11), 2453-2462, 1993
    

Syntheses, structures, and properties of six novel alkali metal tin sulfides: K2Sn2S8, α-Rb2Sn2S8, β-Rb2Sn2S8, K2Sn2S5, Cs2Sn2S6, and Cs2SnS14

MG Kanatzidis, J Liao, C Varotsis
ACS Publications, 1993
    

Resolution of the reaction sequence during the reduction of O2 by cytochrome oxidase

Y Zhang, E Appelman, C Varotsis
National Academy of Sciences, 1993
    

Dioxygen activation and reduction by cytochrome oxidase

G Babcock, C Varotsis
Elsevier BV, 1993
    

Dioxygen Reduction by Cytochrome Oxidase: A Proton-Transfer Limited Reaction

C Varotsis, GT Babcock
Fifth International Conference on the Spectroscopy of Biological Molecules …, 1993
    

[17] Nanosecond time-resolved resonance Raman spectroscopy

CV Arotsis, GT Babcock
Methods in enzymology 226, 409-431, 1993
    

Resolution of the reaction sequence during the reduction of O2 by cytochrome oxidase

C Varotsis, Y Zhang, EH Appelman, GT Babcock
Proceedings of the National Academy of Sciences 90 (1), 237-241, 1993
    

Optical and resonance Raman spectroscopy of the heme groups of the quinol-oxidizing cytochrome aa3 of Bacillus subtilis

M Lauraeus, M Wikstrom, C Varotsis, MMJ Tecklenburg, GT Babcock
Biochemistry 31 (41), 10054-10060, 1992
    

O2 activation in cytochrome oxidase and in other heme proteins

GT Babcock, C Varotsis, Y Zhang
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1101 (2), 192-194, 1992
    

STRUCTURE, SYNTHESIS, AND DIOXYGEN BINDING OF THE HEME OMICRON PROSTHETIC GROUP FROM THE TERMINAL QUINOL OXIDASE OF ESCHERICHIA-COLI

CK CHANG, W WU, C VAROTSIS, GT BABCOCK
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 203, 275-INOR, 1992
    

Structure of the heme o prosthetic group from the terminal quinol oxidase of Escherichia coli

W Wu, CK Chang, C Varotsis, GT Babcock, A Puustinen, M Wikstrom
Journal of the American Chemical Society 114 (4), 1182-1187, 1992
    

Optical and Resonance Raman Spectroscopy of the Heme Groups of the Quinol-Oxidizing Cytochrome a43 of Bacillus subtilist

C Varotsis, J Tecklenburg
Biochemistry 31 (41), 10054-10060, 1992
    

DETECTION AND PHOTOLYSIS OF TRANSIENT SPECIES IN THE CYTOCHROME-OXIDASE O2 REACTION

Y ZHANG, C VAROTSIS, GT BABCOCK
FASEB JOURNAL 6 (1), A202-A202, 1992
    

RESONANCE RAMAN-SPECTROSCOPY OF CYTOCHROME-OO3 AND MODEL COMPOUNDS

C VAROTSIS, W WU, A PUUSTINEN, GT BABCOCK, CK CHANG, …
FASEB JOURNAL 6 (1), A204-A204, 1992
    

Time-resolved resonance Raman detection of intermediates in the reduction of dioxygen by cytochrome oxidase.

CA Varotsis
 
    

Appearance of the. nu.(FeIV: O) vibration from a ferryl-oxo intermediate in the cytochrome oxidase/dioxygen reaction

C Varotsis, GT Babcock
Biochemistry 29 (32), 7357-7362, 1990
    

Direct detection of a dioxygen adduct of cytochrome a3 in the mixed valence cytochrome oxidase/dioxygen reaction.

C Varotsis, WH Woodruff, GT Babcock
Journal of Biological Chemistry 265 (19), 11131-11136, 1990
    

A simple mixer/jet cell for raman spectroscopic studies

C Varotsis, WA Oertling, GT Babcock
Applied spectroscopy 44 (4), 742-744, 1990
    

A simple mixer/jet cell for raman spectroscopic studies

A Oertling, G Babcock, C Varotsis
Publishing Technology, 1990
    

Time-resolved Raman detection of. mu.(Fe-O) in an early intermediate in the reduction of oxygen by cytochrome oxidase

W Woodruff, G Babcock, C Varotsis
ACS Publications, 1990
    

Appearance of the ν (Feiv= O) vibration from a ferry1-oxo intermediate in the cytochrome oxidase/dioxygen reaction

G Babcock, C Varotsis
ACS Publications, 1990
    

Direct detection of a dioxygen adduct of cytochrome a3 in the mixed valence cytochrome oxidase/dioxygen reaction

W Woodruff, G Babcock, C Varotsis
American Society for Biochemistry and Molecular Biology, 1990
    

Time-resolved resonance Raman detection of intermediates in the reduction of dioxygen by cytochrome oxidase

CA Varotsis
Michigan State University. Chemical Physics Program, 1990
    

Time-resolved Raman detection of. mu.(Fe-O) in an early intermediate in the reduction of oxygen by cytochrome oxidase [Erratum to document cited in CA111 (9): 73737r]

C Varotsis, WH Woodruff, GT Babcock
Journal of the American Chemical Society 112 (3), 1297-1297, 1990
    

Time-resolved Raman detection of. nu.(Fe-O) in an early intermediate in the reduction of oxygen by cytochrome oxidase

C Varotsis, WH Woodruff, GT Babcock
Journal of the American Chemical Society 111 (16), 6439-6440, 1989
    

RAMAN-SPECTROSCOPY OF INTERMEDIATES IN HEME PROTEIN CATALYSIS

GT BABCOCK, WA OERTLING, R KEAN, C VAROTSIS, A SALEHI, …
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 197, 19-BIOL, 1989
    

Time-resolved raman detection of v (Fe-O) in an early intermediate in the reduction of O2 by cytochrome oxidase

W Woodruff, G Babcock, C Varotsis
ACS Publications, 1989
    

RESONANCE RAMAN-SCATTERING FROM INTERMEDIATES IN HEME PROTEIN CATALYSIS

WA OERTLING, R KEAN, C VAROTSIS, A SALEHI, CK CHANG, …
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 196, 275-INOR, 1988
    

A resonance Raman study of the higher-lying electronic states of styrene vapor

LD Ziegler, C Varotsis
Chemical physics letters 123 (3), 175-18